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Doxorubicin The selected drug used in cancer treatment for the discussion is Doxorubicin. Doxorubicin is a cytotoxic and antimitotic agent that produces its activity by forming complexes with DNA to inhibit the activity of topoisomerase II activity. The inhibition arises from the stabilization of the DNA-topoisomerase II complex that prevents the relegation aspect of the relegation-litigation reaction catalyzed by topoisomerase II catalyzes. Doxorubicin demonstrates significant differences in its effectiveness when used in individuals from different ethnic backgrounds. An example is a fact that the risk of cardiotoxicity increases by 1.7-fold when Doxorubicin is used in African American patients. Doxorubicin…
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