Validating research assignment

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Validating Research

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Validating Research

How safe and effective is dronabinol (Marinol®) at treating chemotherapy-induced nausea and vomiting? 

            Dronabinol was the second synthetic product of THC medication approved by the Food and Drug Administration (FDA) recommended for adult patients with chemotherapy-induced nausea and vomiting (CINV) following the great effectiveness and safety profile displayed by most clinical trials. As such, Simonian et al. (2020) decided to carry out a comprehensive review to determine the effectiveness and safety of dronabinol in the management of CINV in children. The researchers reviewed other previous studies to be able to answer this research question, hence qualifying this review as a secondary source of data.

Simonian et al. (2020) collected both qualitative and quantitative data from articles selected from medical databases such as PubMed, Embase, and Clinicaltrials.gov. The researchers utilized qualitative studies to determine the extent to which Dronabinol alleviates CINV symptoms among children, in addition to the common side effects and toxicity associated with the use of this medication. On the other hand, quantitative studies were utilized to determine whether there is substantial evidence to support the incorporation of this drug in clinical practice for treating CINV among children.

Based on the study findings, I would prefer utilizing the same approach, a comprehensive literature review, to be able to collect more evidence on the effectiveness and safety of Dronabinol among children with CINV. For instance, from this article, I was able to conclude that the safety of Dronabinol has shown to be acceptable among children with few reported side effects and great effectiveness in managing CINV Simonian et al. (2020).

References

Simonian, J. S., Varanasi, S., Richards, G. J., Van Nguyen, A., Diaz-Fong, J. P., & Le, J. (2020). A critical narrative review of medical cannabis in pediatrics beyond epilepsy, part III: chemotherapy-induced nausea and vomiting and inflammatory bowel disease. Pediatric Medicine, 3, 12–12. https://doi.org/10.21037/pm-20-70

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